Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: Bioequivalence assessment of a single dose of sitagliptin 100 mg of the generic test and the originator reference product under fasting conditions

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques:

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: Pharmacokinetic parameters of a single dose of sitagliptin 100 mg tablet of the generic test and the originator reference product administered under fasting condition

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques:

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: Sitagliptin mean plasma concentration over 72 h following a single dose of a 100 mg tablet of the generic test product (black triangle) and the originator reference product (blue circle) under fasted conditions ( N = 29). Test product: Sitagliptin 100 mg film-coated tablet; Reference product: Januvia 100 mg

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques: Concentration Assay

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: Bioequivalence assessment of a single dose of FDC sitagliptin/metformin tablets 50/850 mg of the generic test and the originator reference product under fed conditions

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques:

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: Bioequivalence assessment of a single dose of FDC sitagliptin/metformin tablets 50/1000 mg of the generic test and the originator reference product under fed conditions

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques:

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: Mean plasma concentration over 48 h for sitagliptin ( a ) and metformin ( b ) following a single dose of a 50/850 mg tablet of the generic test product (black triangle) and the originator reference product (blue circle) under fed conditions ( n = 25 for each drug). Test product: sitagliptin/metformin 50/850 mg film-coated tablet; reference product: Janumet 50/850 mg

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques: Concentration Assay

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: Mean plasma concentration over 48 h for sitagliptin ( a ) and metformin ( b ) following a single dose of a 50/1000 mg tablet of the generic test product (black triangle) and the originator reference product (blue circle) under fed conditions ( n = 24 for each drug). Test product: sitagliptin/metformin 50/1000 mg film-coated tablet; reference product: Janumet 50/1000 mg

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques: Concentration Assay

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: PK parameters of sitagliptin and metformin administered after fed administration of a single dose of a 50/850 mg FDC tablet of the generic test and the originator reference product

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques:

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet: PK parameters of sitagliptin and metformin after fed administration of a single dose of a 50/1000 mg FDC tablet of the generic test and the originator reference product

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques:

Journal: Diabetes Therapy

Article Title: Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin–Metformin Fixed-Dose Combination Compared with the Originator Products

doi: 10.1007/s13300-022-01349-2

Figure Lengend Snippet:

Article Snippet: The sitagliptin study evaluated the bioequivalence of the generic test product “Sitagliptin 100 mg film coated tablet” (containing sitagliptin hydrochloride) with the commercially available originator reference product Januvia 100 mg tablet, distributed by Merck Sharp & Dohme Ltd., Spain (containing sitagliptin phosphate monohydrate).

Techniques: